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Page 1
Evaluation of Kagocel Genotoxicity.
Zhanataev AK, Borovskaya TG, Shcherbakova BS, Rudoi BA, Vychuzhanina AV, Grigor'eva VA, Kamalova SI, Durnev AD. Zhanataev AK, et al. Bull Exp Biol Med. 2019 Apr;166(6):731-734. doi: 10.1007/s10517-019-04428-w. Epub 2019 Apr 24. Bull Exp Biol Med. 2019. PMID: 31020577
DNA comet assay revealed no significant increase in the incidence of DNA breaks in cells of mouse testes after single or multiple administration of Kagocel at daily therapeutic and 10-fold daily therapeutic doses. Our results indicate that Kagocel exhibits no genoto …
DNA comet assay revealed no significant increase in the incidence of DNA breaks in cells of mouse testes after single or multiple administra …
[Safety of the Russian antiviral drug Kagocel].
Borovskaya TG. Borovskaya TG. Ter Arkh. 2017;89(11):93-99. doi: 10.17116/terarkh2017891193-99. Ter Arkh. 2017. PMID: 29260752 Review. Russian.
It is noted that evaluation of the total toxic properties of Kagocel has revealed no signs of intoxication. Investigations of the reproductive toxicity of Kagocel have showed no effect on spermatogenesis. ...The results given in the review lead to the conclusion tha …
It is noted that evaluation of the total toxic properties of Kagocel has revealed no signs of intoxication. Investigations of the rep …
[Kagocel in the therapy of influenza and acute respiratory viral infections: Data analysis and systematization from the results of preclinical and clinical trials].
Sologub TV, Tsvetkov VV. Sologub TV, et al. Ter Arkh. 2017;89(8):113-119. doi: 10.17116/terarkh2017898113-119. Ter Arkh. 2017. PMID: 28914861 Review. Russian.
The article provides the summarized data of clinical trials evaluating the efficacy and safety of kagocel used to prevent and treat influenza and acute respiratory viral infections of different etiologies. The results of numerous preclinical and clinical trials suggest tha …
The article provides the summarized data of clinical trials evaluating the efficacy and safety of kagocel used to prevent and treat i …
[Antiviral effect of "Kagocel" substance in vitro on influenza viruses H1N1, H1N1pdm09 and H3N2.].
Fediakina IT, Konopleva MV, Proshina ES, Linnik EV, Nikitina NI. Fediakina IT, et al. Vopr Virusol. 2019;64(3):125-131. doi: 10.18821/0507-4088-2019-64-3-125-131. Vopr Virusol. 2019. PMID: 31622059 Russian.
MATERIAL AND METHODS: Cytotoxic effect of "Kagocel" substance on MDCK cells had been determined by stained with MTS. ...RESULTS: "Kagocel" substance had low toxicity for MDCK cells. "Kagocel" inhibited the infection titer of influenza virus strains A/Puerto R …
MATERIAL AND METHODS: Cytotoxic effect of "Kagocel" substance on MDCK cells had been determined by stained with MTS. ...RESULTS: " …
Effects of Kagocel on the Counts of Multipotent Stromal Cells, Expression of Cytokine Genes in Primary Cultures of Bone Marrow Stromal Cells, and Serum Cytokine Concentrations in CBA Mice.
Gorskaya YF, Grabko VI, Konopleva MV, Suslov AP, Nesterenko VG. Gorskaya YF, et al. Bull Exp Biol Med. 2015 Jun;159(2):240-4. doi: 10.1007/s10517-015-2932-7. Epub 2015 Jun 20. Bull Exp Biol Med. 2015. PMID: 26087752
The efficiency of cloning of bone marrow multipotent stromal cells (ECF-MSC) from CBA mice and the MSC counts in the femoral bone increased 24 h after a single in vivo (but not in vitro) injection of kagocel (active substance of antiviral drug Kagocel () ) 1.4 times …
The efficiency of cloning of bone marrow multipotent stromal cells (ECF-MSC) from CBA mice and the MSC counts in the femoral bone increased …
Gene Expression Pattern of Peyer's Patch Lymphocytes Exposed to Kagocel Suggests Pattern-Recognition Receptors Mediate Its Action.
Andreev-Andrievskiy AA, Zinovkin RA, Mashkin MA, Frolova OY, Kazaishvili YG, Scherbakova VS, Rudoy BA, Nesterenko VG. Andreev-Andrievskiy AA, et al. Front Pharmacol. 2021 Aug 3;12:679511. doi: 10.3389/fphar.2021.679511. eCollection 2021. Front Pharmacol. 2021. PMID: 34413772 Free PMC article.
Kagocel is a synthetic carboxymethylcellulose derivative copolymerized with gossypol. ...The genes upregulated with kagocel include diverse components of the innate immune defense system....
Kagocel is a synthetic carboxymethylcellulose derivative copolymerized with gossypol. ...The genes upregulated with kagocel in …
Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats.
Borovskaya TG, Poluektova ME, Vychuzhanina AV, Mashanova VA, Shchemerova YA. Borovskaya TG, et al. Bull Exp Biol Med. 2017 Jun;163(2):214-217. doi: 10.1007/s10517-017-3769-z. Epub 2017 Jul 18. Bull Exp Biol Med. 2017. PMID: 28726202
Kagocel did not reduce mating and fertilizing capacities, did not suppress spermatogenesis, and had no toxic effects on the offspring. The results characterize Kagocel as a drug with a broad reproductive safety profile and demonstrate that the age limits for using …
Kagocel did not reduce mating and fertilizing capacities, did not suppress spermatogenesis, and had no toxic effects on the offspring …
Pretreatment with Antiviral Preparation Kagocel Normalizes the Content of Bone Marrow Multipotent Stromal Cells and TNFalpha in Blood Serum of CBA Mice Disturbed by Administration of S. typhimurium Antigen Complex In Vivo and Maintains High Concentration of IL-10 and Th1 Cytokines.
Gorskaya YF, Suslov AP, Semenova EN, Konopleva MV, Nesternko VG. Gorskaya YF, et al. Bull Exp Biol Med. 2017 Oct;163(6):761-765. doi: 10.1007/s10517-017-3898-4. Epub 2017 Oct 24. Bull Exp Biol Med. 2017. PMID: 29063332
Pretreatment with the active substance of antiviral preparation Kagocel, inductor of type I endogenous IFN, in a daily therapeutic dose (30 mug/mouse) 3 h prior to administration of S. typhimurium antigens to CBA mice reduced the number of bone marrow multipotent stromal c …
Pretreatment with the active substance of antiviral preparation Kagocel, inductor of type I endogenous IFN, in a daily therapeutic do …
[Time course of changes in cytokines (IFN-gamma, IFN-alpha, IL-18, TNF-alpha) in the treatment of moderate influenza A (H1N1) pdm09 (2013-2016) with oseltamivir (Tamiflu) and umifenovir (Arbidol) alone and in combination with Kagocel].
Popov AF, Simakova AI, Dmitrenko KA, Shchelkanov MY. Popov AF, et al. Ter Arkh. 2017;89(10):66-70. doi: 10.17116/terarkh2017891066-70. Ter Arkh. 2017. PMID: 29171473 Russian.
AIM: To assess correlation of cytokines levels and therapy regimes a relationship of the time course of changes in the cytokines IFN-gamma, IFN-alpha, IL-18, and TNF-alpha to the treatment option for influenza A (H1N1) pdm09 with umifenovir (Arbidol) 800 mg/day for 5 days (n=50); …
AIM: To assess correlation of cytokines levels and therapy regimes a relationship of the time course of changes in the cytokines IFN-gamma, …
Russian experience in screening, analysis, and clinical application of novel interferon inducers.
Tazulakhova EB, Parshina OV, Guseva TS, Ershov FI. Tazulakhova EB, et al. J Interferon Cytokine Res. 2001 Feb;21(2):65-73. doi: 10.1089/107999001750069926. J Interferon Cytokine Res. 2001. PMID: 11244570 Review.
Cycloferon, Larifan, and Kagocel, which induce IFN formation in lungs, may be effective against influenza and rhinoviral infections. ...Low molecular weight inducers (Amixin, Cycloferon, Kagocel) that penetrate the blood-brain barrier may be active against viral enc …
Cycloferon, Larifan, and Kagocel, which induce IFN formation in lungs, may be effective against influenza and rhinoviral infections. …
25 results