Veterinarski arhiv, Vol. 74 No. 2, 2004.
Izvorni znanstveni članak
Dynamics of concentrations of Ca, Mg, P, and glucose after intravenous administration of complex solutions of calcium, magnesium, phosphorus, and glucose to rabbits.
Saulius Dabužinskas
; Laboratory of Experimental Pharmacology, Department of Internal Diseases, Lithuanian Veterinary Academy, Lithuania
Gintaras Daunoras
; Laboratory of Experimental Pharmacology, Department of Internal Diseases, Lithuanian Veterinary Academy, Lithuania
Algimantas Matusevičius
; Laboratory of Experimental Pharmacology, Department of Internal Diseases, Lithuanian Veterinary Academy, Lithuania
Sažetak
Presented in this article are data of pre-clinical rabbit trials using calcium borogluconate and calcium glycerophosphate injection solution of new composition containing phosphorus and magnesium salts, glucose and caffeine. The dynamics of concentrations of Ca, Mg, P, and glucose in the blood serum were studied. This data was then compared with that of the commercial veterinary medicinal product. When rabbits received an intravenous injection of 21 mg/kg of total calcium, a statistically significant increase in calcium concentration in the blood serum was recorded after 15 and 60 min. It was established that when the inorganic phosphorus contained in sodium dihydrophosphate is administered intravenously it has superior bioavailability than inorganic phosphorus contained in calcium glycerophosphate. Pure phosphorus (7.9 mg/kg) contained in the injected sodium dihydrophosphate salt produced a statistically larger increase in inorganic phosphorus concentration after 15 and 60 min. compared to 10 mg/kg of pure phosphorus contained in the calcium glycerophosphate salt injected. Complex injection solution A1 containing calcium borogluconate, sodium dihydrophosphate, and magnesium chloride, were distinguished by the best bioavailability, and compared to the control solution produced the greatest and longest-lasting increase in concentrations of calcium, magnesium, and inorganic phosphorus in blood serum of rabbits. Newly created complex solutions A1 and A2 of different compositions are suitable for parenteral use and are well tolerated by rabbit organism, and upon intravenous injection produce an increase in total calcium, magnesium, and inorganic phosphorus in the rabbit blood which lasts for several hours.
Ključne riječi
calcium; magnesium; phosphorus; glucose; rabbit; serum
Hrčak ID:
67840
URI
Datum izdavanja:
22.4.2004.
Posjeta: 1.620 *