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Description_x000D_
Application_x000D_
SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies._x000D_
Packaging_x000D_
10 mg in ampule_x000D_
Biochem/physiol Actions_x000D_
SIB 1893 non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 It also acts as a positive allosteric modulator of hmGluR4.2_x000D_
Selective and noncompetitive mGlu5 metabotropic glutamate receptor antagonist._x000D_
Features and Benefits_x000D_
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_
Legal Information_x000D_
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
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